Journal
FEBS LETTERS
Volume 584, Issue 14, Pages 3209-3214Publisher
WILEY
DOI: 10.1016/j.febslet.2010.06.005
Keywords
Iturin family; Antimicrobial activity; Cyclic lipopeptide; Structure elucidation
Funding
- Thailand Research Fund [RMU-4980048]
- Center of Excellence on Environmental Health, Toxicology and Management of Chemicals
- Thailand International Development Cooperation Agency
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Subtulene A, a new cyclic lipopeptide, was isolated from the culture broth of Bacillus subtilis SSE4. This antibiotic compound contained the seven common alpha-amino acids, L-Asn-1, D-Tyr-2, D-Asn-3, L-Gln-4, L-Pro-5, D-Asn-6, L-Ser-7 and the unique beta-amino acid-8 present in the iturin family. 1D and 2D NMR, as well as MS analyses, identified the beta-amino acid as 3-amino-13-methyltetradec-8-enoic acid, an Iso C15 long chain beta-amino acid. B. subtilis SSE4 was also found to produce iturin A. B. subtilis SSE4 culture filtrate exhibited both antifungal and antibacterial activities. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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