Journal
FEBS LETTERS
Volume 584, Issue 22, Pages 4627-4632Publisher
WILEY
DOI: 10.1016/j.febslet.2010.10.036
Keywords
Inflammasome; Poly I:C; RNA virus; IL-1 beta
Funding
- NIAID NIH HHS [R01 AI032972-15, R01 AI025032-24, R37 AI025032-19, K08 AI065878-04, R37 AI025032, R01 AI032972, R01 AI052286-10, K08 AI065878, R01 AI052286, R01 AI032972-20, R01 AI025032] Funding Source: Medline
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Several RNA viruses can be detected by the inflammasome, which promotes IL-1 beta and IL-18 secretion, but the underlying mechanisms of detection remain unclear. Cytosolic dsRNA is a replication intermediate of many RNA viruses. We show here that transfection of the dsRNA analogue poly I: C activates the NLRP3 inflammasome via a pathway requiring endosomal acidification. This detection is independent of the other poly I: C sensors: TLR3 and MDA5. These results suggest a mechanism by which cytosolic dsRNA produced during viral infection could activate the NLRP3 inflammasome. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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