Journal
FEBS LETTERS
Volume 584, Issue 22, Pages 4505-4510Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2010.10.016
Keywords
Hip2; Cyclin B1; Ubiquitination; Apoptosis
Funding
- Korea government [200601742]
- Ministry for Health, Welfare & Family Affairs, the Republic of Korea [A084358]
- Korea Health Promotion Institute [A084358] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Hip2, a ubiquitin conjugating enzyme, is involved in the suppression of cell death. The present study revealed that Hip2 regulates the stability of the apoptotic and cell cycle regulator cyclin B1. Hip2 was found to interact with cyclin B1 to promote its degradation through the ubiquitin proteasome pathway. As a result, Hip2 significantly blocked cell death induced by the cyclin B1 protein, suggesting that Hip2 is involved in the regulation of cyclin B1-mediated cell death. Structured summary: MINT-8045218, MINT-8045231: Hip2 (uniprotkb:P61086) physically interacts (MI:0915) with cyclin-B1 (uniprotkb:P14635) by pull down (MI: 0096) (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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