Journal
FEBS LETTERS
Volume 584, Issue 15, Pages 3359-3365Publisher
WILEY
DOI: 10.1016/j.febslet.2010.06.025
Keywords
Synaptogenesis; Alzheimer disease; Cognition; Neuronal plasticity; Adamantane derivative; Pharmacology; Ciliary neurotrophic factor
Funding
- New York State Office of Mental Retardation and Developmental Disabilities
- EVER Neuro-Pharma, Unterach, Austria
- T.L.L. Temple Foundation
- Alzheimer Association, Chicago, IL
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Development of neurotrophic peptidergic drugs that can mimic neurotrophins and promote neurogenesis and maturation of newborn cells into mature functional neurons represents an exciting therapeutic opportunity for treatment of Alzheimer disease and other learning and memory disorders as well as enhancing cognition of normal individuals. Here we report the design of a peptidergic compound, Ac-DGGL(A)G-NH2, called P21, when administered peripherally, enhanced learning as well as both short-term and spatial reference memories of normal adult C57BI6 mice. P21 induced enhancement of neurogenesis and maturation of newly born neurons in the granular cell layer and subgranular zone of the dentate gyrus. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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