Journal
FEBS LETTERS
Volume 584, Issue 14, Pages 3085-3088Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2010.05.042
Keywords
Tau; Tau secretion; Cerebrospinal fluid; Proteolysis; Exon 2; Cellular model
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Abnormal tau cleavage is prominent in the neurofibrillary degeneration characteristic of Alzheimer's disease (AD) and related tauopathies. We recently showed that cleaved human tau is secreted by specific mechanisms when overexpressed. Here we examined the effect of expressing N-terminal and full length tau constructs in transiently and stably transfected neuronal lines. We show that secreted tau exhibits a cleavage pattern similar to CSF-tau from human AD patients and that tau secretion is specifically inhibited by the presence of the exon 2 insert. These results suggest that tau secretion may play a hitherto unsuspected role in AD and related tauopathies. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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