Journal
FEBS LETTERS
Volume 584, Issue 11, Pages 2381-2386Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2010.04.027
Keywords
GPR41; GPR43; Short chain fatty acid; Leptin; Adipocyte; Lipolysis
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GPR41 is reportedly expressed in murine adipose tissue and mediates short chain fatty acid (SCFA)-stimulated leptin secretion by activating G alpha(i). Here, we agree with a contradictory report in finding no expression of GPR41 in murine adipose tissue. Nevertheless, in the presence of adenosine deaminase to minimise G alpha(i) signalling via the adenosine A1 receptor, SCFA stimulated leptin secretion by adipocytes from wild-type but not GPR41 knockout mice. Expression of GPR43 was reduced in GPR41 knockout mice. Acetate but not butyrate stimulated leptin secretion in wild-type mesenteric adipocytes, consistent with mediation of the response by GPR43 rather than GPR41. Pertussis toxin prevented stimulation of leptin secretion by propionate in epididymal adipocytes, implicating G alpha(i) signalling mediated by GPR43 in SCFA-stimulated leptin secretion. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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