Journal
FEBS LETTERS
Volume 585, Issue 1, Pages 99-103Publisher
WILEY
DOI: 10.1016/j.febslet.2010.11.015
Keywords
Ceramide; Ischemia; Mitochondria; Neuroprotection
Funding
- Banco de Santander
- Universidad Complutense de Madrid
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In this study, we investigated the role of protein kinase C (PKC) and mitochondrial permeability transition pore (mPTP) on the effect of ceramide in an in vitro model of ischemia in SH-SY5Y neuroblastoma cells. In ischemic cell viability studies, a dual effect of ceramide was observed, depending on ceramide concentration. PKC isoforms are involved in the protective effect of low concentrations of ceramide. During ischemia, ceramide treatment leads to an increase in the formation of reactive oxygen species (ROS), which induces a controlled opening of mPTP. This fact prevents mitochondrial Ca2+ overload, which is clearly protective. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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