Journal
FEBS LETTERS
Volume 584, Issue 17, Pages 3675-3681Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2010.05.031
Keywords
ATM; DNA damage and repair; Ionizing radiation; Chromosomal breakage and instability; Cancer
Funding
- NCI NIH HHS [R01 CA071387-14, R01 CA093632-09, R01 CA071387, P30 CA021765, R01 CA093632, P30 CA021765-31] Funding Source: Medline
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The ability of our cells to maintain genomic integrity is fundamental for protection from cancer development. Central to this process is the ability of cells to recognize and repair DNA damage and progress through the cell cycle in a regulated and orderly manner. In addition, protection of chromosome ends through the proper assembly of telomeres prevents loss of genetic information and aberrant chromosome fusions. Cells derived from patients with ataxia-telangiectasia (A-T) show defects in cell cycle regulation, abnormal responses to DNA breakage, and chromosomal end-to-end fusions. The identification and characterization of the ATM (ataxia-telangiectasia, mutated) gene product has provided an essential tool for researchers in elucidating cellular mechanisms involved in cell cycle control, DNA repair, and chromosomal stability. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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