Journal
FEBS LETTERS
Volume 584, Issue 5, Pages 1033-1040Publisher
WILEY
DOI: 10.1016/j.febslet.2010.01.059
Keywords
Apoptosis; Microtubule; Fas/CD95; Lymphocyte
Funding
- Centre National de la Recherche Scientifique (CNRS)
- Ligue nationale contre le cancer (LNCC)
- Institut National du Cancer (INCa)
- Agence Nationale de la Recherche Marie Curie
- Fondation pour la Recherche Medicale (FRM)
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The activation of cysteine-aspartic proteases or caspases and the dynamic arrangement of cytoskeletal components are crucial during apoptosis. Here we describe the fate of Fas downstream of the FasL-induced internalization step, including formation of caspase-dependent SDS-stable Fas complexes, which is mediated by cytoskeleton integrity. We show, in particular, that following FasL treatment, the Fas lower aggregate complex can be co-immunoprecipitated with tubulin and an active form of caspase-8 and that this interaction contributes to the propagation of FasL-induced cell death. The importance of cytoskeletal components during FasL-induced apoptosis is highlighted by our detection of a pool of microtubule-associated Fas complexes. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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