Journal
FEBS LETTERS
Volume 585, Issue 1, Pages 41-46Publisher
WILEY
DOI: 10.1016/j.febslet.2010.11.017
Keywords
Influenza virus; Nuclear export; NS2; M1; vRNP
Funding
- G-COE program
- Nagasaki University
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The influenza virus genome replicates in the host cell nucleus, and the progeny viral ribonucleoproteins (vRNPs) are exported to the cytoplasm prior to maturation. The influenza virus NS2 protein has a nuclear export signal (NES) and binds to M1. It is therefore postulated that vRNP is exported from the nucleus by binding to NS2 through M1. However, the significance of the association between NS2 and M1 for the nuclear export of vRNP is still poorly understood. We herein demonstrate that the C-terminal domain of NS2 (residues 81-100) is essential for M1 binding and the nuclear export of progeny vRNPs. Structured summary: MINT-8057301, MINT-8057317:NS2 (uniprotkb:P03508) binds (MI:0407) to M1 (uniprotkb:P03485) by pull down (MI:0096) (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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