Journal
FEBS LETTERS
Volume 584, Issue 10, Pages 2093-2101Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2010.01.027
Keywords
Chloride intracellular channel protein; Redox; Membrane insertion; Tubulogenesis; CLIC1
Funding
- Australian National Health and Medical Research Council
- Australian Research Council (ARC)
- ARC APD
- Italian Ministry of University and Scientific Research
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Chloride intracellular channel proteins (CLICs) are distinct from most ion channels in that they have both soluble and integral membrane forms. CLICs are highly conserved in chordates, with six vertebrate paralogues. CLIC-like proteins are found in other metazoans. CLICs form channels in artificial bilayers in a process favoured by oxidising conditions and low pH. They are structurally plastic, with CLIC1 adopting two distinct soluble conformations. Phylogenetic and structural data indicate that CLICs are likely to have enzymatic function. The physiological role of CLICs appears to be maintenance of intracellular membranes, which is associated with tubulogenesis but may involve other substructures. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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