Journal
FEBS LETTERS
Volume 584, Issue 16, Pages 3609-3614Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2010.07.033
Keywords
Antioxidant enzyme; Drosophila; Forkhead box O; Lifespan; Longevity; Methionine sulfoxide reductase A; Oxidative stress; Transcription; Translocation
Funding
- National Research Foundation of Korea [2008-0061669, 2010-0000846]
- KRIBB Research Initiative
- Ministry of Education, Science and Technology, Republic of Korea [M107 1118001-08M1118-00110]
- National Research Foundation of Korea [2008-0061669] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Methionine sulfoxide reductase A (msrA) was previously found to increase resistance to oxidative stress and longevity in animals. We identified Drosophila msrA (dmsrA), a Drosophila homolog of human msrA, as a downstream effector of forkhead box O (FOXO) signaling in Drosophila, which enhances resistance to oxidative stress and increases survival under stressed conditions. Additionally, overexpression of dmsrA in neurons extended the lifespan of flies. Moreover, overexpression of dmsrA in fat body cells caused FOXO to translocate to the nucleus, implying that this possible positive feedback loop between dmsrA and FOXO could potentiate the antioxidant activity of dmsrA and increase the lifespan in Drosophila. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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