Journal
FEBS LETTERS
Volume 584, Issue 9, Pages 1728-1740Publisher
WILEY
DOI: 10.1016/j.febslet.2010.02.026
Keywords
Ceramide; Platforms; ASMase
Funding
- NIH [CA85704]
Ask authors/readers for more resources
Recent evidence suggests that ceramide regulates stress signaling via reorganization of the plasma membrane. The focus of this review will be to discuss the mechanism by which acid sphingomyelinase (ASMase)-generated ceramide initiates transmembrane signaling in the plasma membrane exoplasmic leaflet. In particular, we review the unique biophysical properties of ceramide that render it proficient in formation of signaling domains termed ceramide-rich platforms (CRPs), and the role of CRPs in the pathophysiology of various diseases. The biomedical significance of CRPs makes these structures an attractive therapeutic target. (C) 2010 Published by Elsevier B. V. on behalf of the Federation of European Biochemical Societies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available