Journal
FEBS LETTERS
Volume 584, Issue 13, Pages 2807-2815Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2010.05.016
Keywords
SPAG8; ACT; CREM tau; Transcriptional activation; Spermatogenesis
Funding
- National Important Research Plan of China [2006CB944002]
- National Basic Research Program of China [2006CB504001]
- Ministry of Science and Technology of China
- Creative Research Group [30721063]
- National Natural Science Foundation of China [2060204]
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cAMP response element modulator (CREM)-mediated gene expression is an essential regulatory mechanism for germ cell differentiation. CREM and its coactivator in testis, ACT, activate the transcription of many essential genes for spermatogenesis. Sperm associated antigen 8 (SPAG8) is a testis-specific component that is expressed during germ cell differentiation. In this study, we found the pattern of SPAG8 expression largely overlapped with that of ACT during spermatogenesis and verified the association of SPAG8 with ACT. Furthermore, we showed that SPAG8 enhanced the transcriptional activation of ACT-mediated CREM tau by strengthening the binding of ACT to CREM tau. These results indicate that SPAG8 acts as a regulator of ACT and plays an important role in CREM-ACT-mediated gene transcription during spermatogenesis.
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