Journal
FEBS LETTERS
Volume 584, Issue 13, Pages 2896-2900Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2010.05.008
Keywords
Lipocalin; Sequence motif; Lopap; Apoptosis; Cell survival
Funding
- Brazilian agencies: Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP, CAT/CEPID)
- Conselho Nacional de Pesquisa e Desenvolvimento/Instituto Nacional de Ciencia e Tecnologia (CNPq/INCT)
- Financiadora de Estudos e Projetos (FINEP)
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Lipocalins are beta-barrel proteins, which share three conserved motifs in their amino acid sequence. In this study, we identified by a peptide mapping approach, a seven-amino acid sequence related to one of these motifs (motif 2) that modulates cell survival. A synthetic peptide based on an insect lipocalin displayed cytoprotective activity in serum-deprived endothelial cells and leucocytes. This activity was dependent on nitric oxide synthase. This sequence was found within several lipocalins, including apolipoprotein D, retinol binding protein, lipocalin-type prostaglandin D synthase, and many unknown proteins, suggesting that it is a sequence signature and a lipocalin conserved property. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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