Journal
FEBS LETTERS
Volume 583, Issue 24, Pages 3966-3973Publisher
WILEY
DOI: 10.1016/j.febslet.2009.10.036
Keywords
mRNA; Protein; Quantitative; Systems biology; Genomics; Proteomics
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The correlation between mRNA and protein abundances in the cell has been reported to be notoriously poor. Recent technological advances in the quantitative analysis of mRNA and protein species in complex samples allow the detailed analysis of this pathway at the center of biological systems. We give an overview of available methods for the identification and quantification of free and ribosome-bound mRNA, protein abundances and individual protein turnover rates. We review available literature on the correlation of mRNA and protein abundances and discuss biological and technical parameters influencing the correlation of these central biological molecules. (c) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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