Journal
FEBS LETTERS
Volume 583, Issue 6, Pages 971-977Publisher
WILEY
DOI: 10.1016/j.febslet.2009.02.028
Keywords
eIF3f; Cyclin-dependent kinase 11; Translation initiation; Phosphorylation; Apoptosis; Melanoma
Funding
- Cancer Biology Training Grant [CA 09213]
- University of Arizona [0007, CA133449]
- GI SPORE [CA095060, CA70145, GM22135]
- Center Grants [ES066694]
- NIH Arizona Cancer Center [CA023074]
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eIF3f is a subunit of eukaryotic initiation factor 3 (eIF3). We previously showed that eIF3f is phosphorylated by cyclin dependent kinase 11 (CDK11(p46)) which is an important effector in apoptosis. Here, we identified a second eIF3f phosphorylation site (Thr119) by CDK11(p46) during apoptosis. We demonstrated that eIF3f is directly phosphorylated by CDK11(p46) in vivo. Phosphorylation of eIF3f plays an important role in regulating its function in translation and apoptosis. Phosphorylation of eIF3f enhances the association of eIF3f with the core eIF3 subunits during apoptosis. Our data suggested that eIF3f may inhibit translation by increasing the binding to the eIF3 complex during apoptosis.
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