Journal
FEBS LETTERS
Volume 584, Issue 3, Pages 531-536Publisher
WILEY
DOI: 10.1016/j.febslet.2009.11.092
Keywords
Gallic acid; GLUT4 translocation; Glucose uptake; Atypical protein kinase; Akt inhibitor
Funding
- Council of Scientific and Industrial Research, Govt. of India [38(1216)/09]
Ask authors/readers for more resources
GLUT4, a 12 transmembrane protein, plays a major role in insulin mediated glucose transport in muscle and adipocytes. For glucose transport, the GLUT4 protein needs to be translocated to the plasma membrane from the intracellular pool and it is possible that certain compounds may be able to enhance this process. In the present work, we have shown that gallic acid can increase GLUT4 translocation and glucose uptake activity in an Akt-independent but wortmannin-sensitive manner. Further analysis suggested the role of atypical protein kinase C zeta/lambda in gallic acid mediated GLUT4 translocation and glucose uptake. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available