Journal
FEBS LETTERS
Volume 583, Issue 4, Pages 680-684Publisher
WILEY
DOI: 10.1016/j.febslet.2009.01.011
Keywords
ERK8; MAPK; DNA damage; MMS
Funding
- UK Medical Research Council
- The Royal Society
- AstraZeneca
- Boehringer Ingelheim
- GlaxoSmithKline
- Merck KGaA
- Pfizer
- Medical Research Council [MC_U127084348] Funding Source: researchfish
- MRC [MC_U127084348] Funding Source: UKRI
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We have investigated the agonists that activate transfected extracellular signal-regulated kinase 8 (ERK8) in cells, and have found that the most potent activators are hydrogen peroxide, DNA alkylating and cross-linking agents and the poly (ADP-ribose) polymerase inhibitor KU-0058948. The feature shared by all these agents is that they lead to the accumulation of single strand breaks in DNA, suggesting a role for ERK8 in the response to, or repair of, DNA single strand breaks. The DNA alkylating agent MMS also induced the disappearance of endogenous ERK8 by a proteasome-dependent mechanism. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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