Journal
FEBS LETTERS
Volume 583, Issue 8, Pages 1267-1273Publisher
WILEY
DOI: 10.1016/j.febslet.2009.02.041
Keywords
Mitochondria; Directed movement; Docked/anchored mitochondria; Brownian diffusion; Single particle tracking; Computer aided analysis
Funding
- Science and Technology Funding Council [ST/F003722]
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The apparently stationary phase of mitochondrial motion was investigated in epithelial cells by spinning disk confocal light microscopy combined with image correlation based single particle tracking using custom software producing sub-pixel accuracy measurements (similar to 5 nm) at 10-12 Hz frame-rates. The analysis of these data suggests that the previously described stationary, or anchored phase, in mitochondrial movement actually comprise Brownian diffusion, interspersed with frequent and brief motor-driven events whose duration are stochastically determined. We have therefore discovered a new aspect of mitochondrial behavior, which we call stochastically determined, directed movement. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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