Journal
FEBS LETTERS
Volume 583, Issue 12, Pages 2042-2048Publisher
WILEY
DOI: 10.1016/j.febslet.2009.05.016
Keywords
Oxidative stress; Human adipocytes; Apolipoprotein E; Antioxidant; Obesity; SW872
Funding
- Ministere de l'Enseignement Superieur et de la Recherche
- Ministere de l'Outre-Mer
- Conseil Regional de La Reunion
- Universite de La Reunion
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Oxidative stress in adipose tissue constitutes a pathological process involved in obesity-linked metabolic disorders. Apolipoprotein E (apoE), which exhibits antioxidant properties in plasma and brain, is highly produced by adipose tissue and adipocytes. In this study, we investigated the role of apoE in the human adipocyte response to oxidative stress. We first demonstrated that apoE secretion by adipocytes was stimulated by oxidative stress. We also observed that apoE overexpression protected adipocytes from hydrogen peroxide-induced damages, by mitigating intracellular oxidation and exerting extracellular antioxidant properties. Our findings clearly show a novel antioxidant role for apoE in adipose tissue. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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