Journal
FEBS LETTERS
Volume 583, Issue 6, Pages 1029-1033Publisher
WILEY
DOI: 10.1016/j.febslet.2009.02.031
Keywords
Adipogenesis; Adipocyte; Stem cell; Differentiation
Funding
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- Grants-in-Aid for Scientific Research [20114007] Funding Source: KAKEN
Ask authors/readers for more resources
Induced pluripotent stem (iPS) cells were recently established from human fibroblasts. In the present study we investigated the adipogenic differentiation properties of four human iPS cell lines and compared them with those of two human embryonic stem (ES) cell lines. After 12 days of embryoid body formation and an additional 10 days of differentiation on Poly-L-ornithine and fibronectin-coated dishes with adipogenic differentiation medium, human iPS cells exhibited lipid accumulation and transcription of adipogenesis-related molecules such as C/EBP alpha, PPAR gamma 2, leptin and aP2. These results demonstrate that human iPS cells have an adipogenic potential comparable to human ES cells. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available