Journal
FEBS LETTERS
Volume 584, Issue 9, Pages 1678-1684Publisher
WILEY
DOI: 10.1016/j.febslet.2009.10.051
Keywords
Cell membrane; Lipid microdomain; Theory; Modeling
Funding
- NSF at Princeton University [DMR-0449184, DMR-0213706]
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Compositional lipid microdomains (lipid raft) in plasma membranes are believed to be important components of many cellular processes. The biophysical mechanisms by which cells regulate the size, lifetime, and spatial localization of these domains are rather poorly understood at the moment. Over the years, experimental studies of raft formation have inspired several phenomenological theories and speculations incorporating a wide variety of thermodynamic assumptions regarding lipid-lipid and lipid-protein interactions, and the potential role of active cellular processes on membrane structure. Here we critically review and discuss these theories, models, and speculations, and present our view on future directions. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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