Journal
FEBS LETTERS
Volume 583, Issue 10, Pages 1567-1574Publisher
WILEY
DOI: 10.1016/j.febslet.2009.04.022
Keywords
Epstein-Barr virus; Latent membrane protein 1; BS69; NF-kappa B; TNFR-associated death domain protein
Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan
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Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) activates NF-kappa B signaling pathways through the two C-terminal regions, CTAR1 and CTAR2. BS69 has previously been shown to be involved in LMP1-induced c-Jun N-terminal kinase activation through CTAR2 by interacting with tumor necrosis factor (TNFR) receptor-associated factor 6. In the present study, our manipulation of BS69 expression clearly indicates that BS69 negatively regulates LMP1-mediated NF-kappa B activation and up-regulates IL-6 mRNA expression and I kappa B degradation. Our immunoprecipitation experiments suggest that BS69 decreases complex formation between LMP1 and TNFR-associated death domain protein (TRADD).
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