Journal
FEBS LETTERS
Volume 583, Issue 24, Pages 3938-3947Publisher
WILEY
DOI: 10.1016/j.febslet.2009.11.021
Keywords
Biological oscillator; Circadian rhythm; Mathematical model; Cyanobacteria; Multisite phosphorylation; KaiC
Funding
- Howard Hughes Medical Institute Funding Source: Medline
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The circadian clock of the cyanobacterium Synechococcus elongatus PCC 7942 is governed by a core oscillator consisting of the proteins KaiA, KaiB, and KaiC. Remarkably, circadian oscillations in the phosphorylation state of KaiC can be reconstituted in a test tube by mixing the three Kai proteins and adenosine triphosphate. The in vitro oscillator provides a well-defined system in which experiments can be combined with mathematical analysis to understand the mechanism of a highly robust biological oscillator. In this Review, we summarize the biochemistry of the Kai proteins and examine models that have been proposed to explain how oscillations emerge from the properties of the oscillator's constituents. (c) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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