Journal
FEBS LETTERS
Volume 583, Issue 24, Pages 3999-4005Publisher
WILEY
DOI: 10.1016/j.febslet.2009.10.068
Keywords
Systems biology; Oocyte maturation; Embryonic cell cycle; CDK1; Cyclin; MAP kinase; Xenopus
Funding
- NIGMS NIH HHS [R01 GM046383] Funding Source: Medline
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Here we review some of our work over the last decade on Xenopus oocyte maturation, a cell fate switch, and the Xenopus embryonic cell cycle, a highly dynamical process. Our approach has been to start with wiring diagrams for the regulatory networks that underpin the processes; carry out quantitative experiments to describe the response functions for individual legs of the networks; and then construct simple analytical models based on chemical kinetic theory and the graphical rate-balance formalism. These studies support the view that the all-or-none, irreversible nature of oocyte maturation arises from a saddle-node bifurcation in the regulatory system that drives the process, and that the clock-like oscillations of the embryo are built upon a hysteretic switch with two saddle-node bifurcations. We believe that this type of reductionistic systems biology holds great promise for understanding complicated biochemical processes in simpler terms. (c) 2009 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
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