Journal
FEBS LETTERS
Volume 584, Issue 2, Pages 265-271Publisher
WILEY
DOI: 10.1016/j.febslet.2009.11.049
Keywords
tRNA; Modification; Degradation; Methylation; Thiolation; Editing
Funding
- National Institutes of Health [GM52347, GM084065]
- National Science Foundation [MCB0620707]
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Despite the universality of tRNA modifications, some tRNAs lacking specific modifications are subject to degradation pathways, while other tRNAs lacking the same modifications are resistant. Here, we suggest a model in which some modifications have minor, possibly redundant, roles in specific tRNAs. This model is consistent with the low specificity of some modification enzymes. Limitations of this model include the limited assays and growth conditions on which these conclusions are based, as well as the high specificity exhibited by many modification enzymes with important roles in translation. The specificity of these enzymes is often enhanced by complex substrate recognition patterns and sub-cellular compartmentalization. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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