Journal
FEBS LETTERS
Volume 584, Issue 7, Pages 1427-1435Publisher
WILEY
DOI: 10.1016/j.febslet.2009.12.034
Keywords
Autophagy; Cancer; Genome instability; Cell death; Chemotherapy
Funding
- NIH [RO1CA126792, CA126792-S1 ARRA]
- California Tobacco Related Disease Research Program [18XT-0106]
- HHMI Physician Scientist Early Career Award
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Autophagy, or cellular self-digestion, is activated in cancer cells in response to multiple stresses and has been demonstrated to promote tumor cell survival and drug resistance. Nonetheless, genetic evidence supports that autophagy functions as a tumor suppressor mechanism. Hence, the precise role of autophagy during cancer progression and treatment is both tissue and context dependent. Here, we discuss our current understanding of the biological functions of autophagy during cancer development, overview how autophagy is regulated by cancer-associated signaling pathways, and review how autophagy inhibition is being exploited to improve clinical outcomes. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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