Journal
FEBS LETTERS
Volume 584, Issue 2, Pages 376-386Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2009.11.061
Keywords
tRNA; Flexibility; Conformational change; Induced fit; Molecular dynamics; Translation
Funding
- NSF [MCB-0448243, MCB-0844670, PHY-0822613]
- National Foundation for Cancer Research
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [0844670] Funding Source: National Science Foundation
- Direct For Mathematical & Physical Scien
- Division Of Physics [0822613] Funding Source: National Science Foundation
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As the molecular representation of the genetic code, tRNA plays a central role in the translational machinery where it interacts with several proteins and other RNAs during the course of protein synthesis. These interactions exploit the dynamic flexibility of tRNA. In this minireview, we discuss the effects of modified bases, ions, and proteins on tRNA structure and dynamics and the challenges of observing its motions over the cycle of translation. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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