Journal
FEBS LETTERS
Volume 584, Issue 2, Pages 297-302Publisher
WILEY
DOI: 10.1016/j.febslet.2009.10.078
Keywords
tRNA; Nucleotidyltransferase; ATP(CTP):tRNA nucleotidyltransferase; CCA-adding enzyme
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tRNA-nucleotidyltransferases are fascinating and unusual RNA polymerases responsible for the synthesis of the nucleotide triplet CCA at the 3'-terminus of tRNAs. As this CCA end represents an essential functional element for aminoacylation and translation, these polymerases (CCA-adding enzymes) are of vital importance in all organisms. With a possible origin of ancient telomerase-like activity, the CCA-adding enzymes obviously emerged twice during evolution, leading to structurally different, but functionally identical enzymes. The evolution as well as the unique polymerization features of these interesting proteins will be discussed in this review. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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