Journal
FEBS LETTERS
Volume 584, Issue 9, Pages 1741-1747Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2009.10.011
Keywords
Ganglioside; Myelin; Myelin-associated glycoprotein; Axon regeneration; Lectin
Funding
- National Institutes of Health, National Institute of Neurological Disorders and Stroke [NS037096, NS057338]
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Gangliosides, sialic acid-bearing glycosphingolipids, are expressed at high abundance and complexity in the brain. Altered ganglioside expression results in neural disorders, including seizures and axon degeneration. Brain gangliosides function, in part, by interacting with a ganglioside-binding lectin, myelin-associated glycoprotein (MAG). MAG, on the innermost wrap of the myelin sheath, binds to gangliosides GD1a and GT1b on axons. MAG-ganglioside binding ensures optimal axon-myelin cell-cell interactions, enhances long-term axon-myelin stability and inhibits axon outgrowth after injury. Knowledge of the molecular interactions of brain gangliosides may improve understanding of axon-myelin stability and provide opportunities to enhance recovery after nerve injury. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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