Journal
FEBS LETTERS
Volume 584, Issue 2, Pages 427-433Publisher
WILEY
DOI: 10.1016/j.febslet.2009.11.037
Keywords
Dual localization; Aminoacylation; tRNA; Mitochondria; Metabolism; Saccharomyces cerevisiae
Funding
- University of Strasbourg
- Centre National de la Recherche Scientifique (CNRS)
- Agence Nationale de la Recherche [ANR-09-BLAN-0091-02]
- Association pour la Recherche sur le Cancer (ARC)
- Association Francaise contre les Myopathies (AFM)
- Agence Nationale de la Recherche (ANR) [ANR-09-BLAN-0091] Funding Source: Agence Nationale de la Recherche (ANR)
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Accurate synthesis of aminoacyl-tRNAs (aa-tRNA) by aminoacyl-tRNA synthetases (aaRS) is an absolute requirement for errorless decoding of the genetic code and is studied since more than four decades. In all three kingdoms of life aaRSs are capable of assembling into multi-enzymatic complexes that are held together by auxiliary non-enzymatic factors, but the role of such macromolecular assemblies is still poorly understood. In the yeast Saccharomyces cerevisiae, Arc1p holds cytosolic methionyl-tRNA synthetase (cMRS) and glutamyl-tRNA synthetase (cERS) together and plays an important role in fine tuning several cellular processes like aminoacylation, translation and carbon source adaptation. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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