Journal
FEBS LETTERS
Volume 583, Issue 24, Pages 4006-4012Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2009.09.045
Keywords
Signal transduction; Spatial gradient; Protein modification cycle; Spatiotemporal dynamic
Funding
- NHLBI NIH HHS [R33HL088283, R33 HL088283] Funding Source: Medline
- NIGMS NIH HHS [R01 GM059570, R01 GM059570-08A1, GM059570] Funding Source: Medline
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Emerging evidence indicates that complex spatial gradients and (micro) domains of signalling activities arise from distinct cellular localization of opposing enzymes, such as a kinase and phosphatase, in signal transduction cascades. Often, an interacting, active form of a target protein has a lower diffusivity than an inactive form, and this leads to spatial gradients of the protein abundance in the cytoplasm. A spatially distributed signalling cascade can create step-like activation profiles, which decay at successive distances from the cell surface, assigning digital positional information to different regions in the cell. Feedback and feedforward network motifs control activity patterns, allowing signalling networks to serve as cellular devices for spatial computations. (c) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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