4.5 Review

Cells and prions: A license to replicate

Journal

FEBS LETTERS
Volume 583, Issue 16, Pages 2674-2684

Publisher

WILEY
DOI: 10.1016/j.febslet.2009.06.014

Keywords

Prion replication competence; Follicular dendritic cell; Stromal inflammatory cell; Neuroinvasion; Mesenchymal progenitor cell

Funding

  1. Bundesamt fur Bildung und Wissenschaft
  2. Ernst-Jung-Foundation
  3. Stammbach foundation
  4. ImmunoPrion [FP6-Food-023144, 2006-2009]
  5. Swiss National Science Foundation
  6. NCCR
  7. Bonizzi-Theler foundation
  8. Swiss MS Society
  9. Prof. Dr. Max Cloetta foundation
  10. Research at the Medical faculty, University of Zurich
  11. Collegio Ghislieri, Pavia, Italy

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Prion diseases are neurodegenerative, infectious disorders characterized by the aggregation of a misfolded isoform of the cellular prion protein (PrPC). The infectious agent - termed prion - is mainly composed of misfolded PrPSc. In addition to the central nervous system prions can colonize secondary lymphoid organs and inflammatory foci. Follicular dendritic cells are important extraneural sites of prion replication. However, recent data point to a broader range of cell types that can replicate prions. Here, we review the state of the art in regards to peripheral prion replication, neuroinvasion and the determinants of prion replication competence. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

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