Journal
FEBS LETTERS
Volume 584, Issue 1, Pages 207-212Publisher
WILEY
DOI: 10.1016/j.febslet.2009.11.062
Keywords
Endotoxin; Macrophage; Lipid A; Outer membrane; Gram-negative bacteria
Funding
- JSPS
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Modification of lipid A is essential for bacterial adaptation to its host. Salmonella Typhimurium LpxR potentially detoxifies lipid A by 3'-O-deacylation; however, the involvement of deacylation in its adaptation remains unclear. LpxR-dependent 3'-O-deacylation was observed in the stationary phase. When macrophages were infected with stationary phase bacteria, the intracellular growth of the lpxR-null strain was lower than that of the wild-type strain. Furthermore, the expression level of inducible nitric oxide synthase was higher in the cells infected with the lpxR-null strain than in the cells infected with the wild-type strain. These results indicate that lipid A 3'-O-deacylation is beneficial for intracellular growth. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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