Journal
FEBS LETTERS
Volume 583, Issue 13, Pages 2263-2268Publisher
WILEY
DOI: 10.1016/j.febslet.2009.06.006
Keywords
miR-210; Differentiation; Osteoblast; Activin A receptor type 1B
Funding
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan
- Saitama Medical University
- Research Center for Genomic Medicine
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Although microRNAs (miRNAs) are involved in many biological processes, the mechanisms whereby miRNAs regulate osteoblastic differentiation are poorly understood. Here, we found that BMP-4-induced osteoblastic differentiation of bone marrow-derived ST2 stromal cells was promoted and repressed after transfection of sense and antisense miR-210, respectively. A reporter assay demonstrated that the activin A receptor type 1B (AcvR1b) gene was a target for miR-210. Furthermore, inhibition of transforming growth factor-beta (TGF-beta)/activin signaling in ST2 cells with SB431542 promoted osteoblastic differentiation. We conclude that miR-210 acts as a positive regulator of osteoblastic differentiation by inhibiting the TGF-beta/activin signaling pathway through inhibition of AcvR1b. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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