Journal
FEBS LETTERS
Volume 583, Issue 10, Pages 1619-1624Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2009.04.031
Keywords
Transient receptor potential vanilloid-1; Human dendritic cell; Differentiation; Cytokine release; Anti-inflammatory
Funding
- Hungarian Research Grants [OTKA T049231, OTKA K63153, ETT 480/2006, ETT 482/2006, RET 06/2004]
- Hungarian Academy of Sciences
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The goal of the current study was to investigate the expression of transient receptor potential vanilloid-1 (TRPV1) on human in vitro differentiated monocyte-derived dendritic cells (DCs) and to dissect the corresponding role of TRPV1-signaling in DC-specific functions. TRPV1 expression was identified both at the protein and gene levels in human DCs. Moreover, the prototypic TRPV1 agonist capsaicin specifically (i.e. via TRPV1) and dose-dependently inhibited cytokine-induced DC differentiation, phagocytosis of bacteria, activation of DCs, and pro-inflammatory cytokine secretion. These data introduce TRPV1-coupled signaling as a novel player in human monocyte-derived DC biology with anti-inflammatory actions. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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