Journal
FEBS LETTERS
Volume 583, Issue 8, Pages 1215-1225Publisher
WILEY
DOI: 10.1016/j.febslet.2009.03.038
Keywords
Homocysteine; Cholesterol; Choline; Phosphatidylcholine; Betaine; Methionine
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An association between hyperlipidemia and hyperhomocysteinemia (HHCY) has been suggested. This link is clinically important in management of vascular risk factors especially in elderly people and patients with metabolic syndrome. Higher plasma homocysteine (Hcy) was associated with lower high-density lipoprotein (HDL)-cholesterol level. Moreover, HHCY was associated with disturbed plasma lipids or fatty liver. It seems that hypomethylation associated with HHCY is responsible for lipid accumulation in tissues. Decreased methyl group will decrease the synthesis of phosphatidylcholine, a major phospholipid required for very low-density lipoprotein ( VLDL) assembly and homeostasis. The effect of Hcy on HDL-cholesterol is probably related to inhibiting enzymes or molecules participating in HDL-particle assembly. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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