Journal
FEBS LETTERS
Volume 583, Issue 4, Pages 777-781Publisher
WILEY
DOI: 10.1016/j.febslet.2009.01.022
Keywords
Liver regeneration; Oval cell; Wnt; beta-Catenin
Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [17014016]
- CREST program of Japan Science and Technology Agency
- Grants-in-Aid for Scientific Research [17014016] Funding Source: KAKEN
Ask authors/readers for more resources
In injured livers where hepatocyte growth is severely limited, facultative hepatic stem/progenitor cells, termed oval cells in rodents, are known to emerge and contribute to the regeneration process. Here, we investigated a possible involvement of Wnt signaling during mouse oval cell response and found significant upregulation of several Wnt genes including Wnt7a, Wnt7b, and Wnt10a. Accordingly, increase of beta-catenin protein was observed in oval cell compartments. Pharmacological activation of the canonical Wnt/beta-catenin signaling induced proliferation of cultured hepatic stem/progenitor cell lines. These results together implicate the role of Wnt/beta-catenin signaling in adult hepatic stem/progenitor cell response. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available