Journal
FEBS LETTERS
Volume 583, Issue 4, Pages 697-702Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2009.01.010
Keywords
Triterpene glycosides; Frondoside A; Apoptosis; Caspase; Leukemia
Funding
- Korea Science and Engineering Foundation (KOSEF)
- Dong-A University [R13-2002-044-04001-0]
- State Contract of FASI [02.522.11.2013]
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Frondoside A is a pentaoside having an acetyl moiety at the aglycon ring and xylose as a third monosaccharide residue. Cucumarioside A(2)-2 is a pentaoside having glucose as a third monosaccahride unit. We compared the effects of frondoside A and A(2)-2 for cell death-inducing capability with close attention paid to structure-activity relationships. Both frondoside A and A(2)-2 strongly induced apoptosis of leukemic cells. Frondoside A-induced apoptosis was more potent and rapid than A(2)-2-induced apoptosis. A(2)-2-induced but not frondoside A-induced apoptosis was caspase-dependent. This suggests that holothurians may induce apoptosis of leukemic cells caspase-dependently or -independently, depending on the holothurian structure. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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