Journal
FEBS LETTERS
Volume 583, Issue 3, Pages 561-567Publisher
WILEY
DOI: 10.1016/j.febslet.2008.12.061
Keywords
Human embryonic stem cells; Oligodendrocytes; Vitronectin; Differentiation
Funding
- Seoul Research and Business Development Program [10574]
- Korea Science and Engineering Foundation (KOSEF)
- Korea Government (MOST) [R01-2006-000-11364-0]
- National Research Foundation of Korea [R01-2006-000-11364-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Ask authors/readers for more resources
We demonstrate enhanced differentiation of oligodendrocytes during neurogenesis of human embryonic stem cells (hESCs) using an extracellular matrix protein, vitronectin (VN). We show that VN is expressed in the ventral part of the developing human spinal cord. Combined treatment of retinoic acid, sonic hedgehog, and noggin in the presence of VN allows hESCs to differentiate into O4-positive oligodendrocytes. Particularly, VN profoundly promotes the derivation of oligodendrocyte progenitors that proliferate and differentiate into oligodendrocytes in response to mitogenic and survival factors. These results support the beneficial effect of VN on oligodendrocytic differentiation of hESCs. (c) 2009 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
