Journal
FEBS LETTERS
Volume 583, Issue 9, Pages 1427-1433Publisher
WILEY
DOI: 10.1016/j.febslet.2009.03.040
Keywords
Cryptochrome; Photolyase; Blue light; Photoreceptor; ATP; Arabidopsis thaliana
Funding
- US National Science Foundation [0343737]
- French ministry of research
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [0343737] Funding Source: National Science Foundation
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Cryptochromes are widely distributed blue light photoreceptors involved in numerous signaling functions in plants and animals. Both plant and animal-type cryptochromes are found to bind ATP and display intrinsic autokinase activity; however the functional significance of this activity remains a matter of speculation. Here we show in purified preparations of Arabidopsis cry1 that ATP binding induces conformational change independently of light and increases the amount and stability of light-induced flavin radical formation. Nucleotide binding may thereby provide a mechanism whereby light responsivity in organisms can be regulated through modulation of cryptochrome photoreceptor conformation. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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