Journal
FEBS LETTERS
Volume 583, Issue 6, Pages 1023-1028Publisher
WILEY
DOI: 10.1016/j.febslet.2009.02.027
Keywords
Tie-1; Endothelial inflammation; Microarray; U937
Funding
- NIDDK Mentored Research Scientist Development Award [1K01DK077727]
- Beth Israel Deaconess Medical Center
Ask authors/readers for more resources
Tie-1 is an endothelial specific receptor tyrosine kinase that is upregulated in diseases such as atherosclerosis and rheumatoid arthritis. We recently demonstrated that Tie-1 induced a proinflammatory response when overexpressed in endothelial cells. Here, we used a complementary approach and suppressed endogenous Tie-1 expression in endothelial cells to examine its function by microarray analysis. Tie-1 appeared to govern expression of many genes involved in inflammation. Expression knockdown of Tie-1 significantly reduced endothelial conditioned medium ability to stimulate MCP-1 production in U937 cells. Collectively, our results support the notion that Tie-1 has an inflammatory function in endothelial cells. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available