Journal
FEBS LETTERS
Volume 583, Issue 17, Pages 2882-2886Publisher
WILEY
DOI: 10.1016/j.febslet.2009.07.053
Keywords
Fibroblast growth factor 21; Carbohydrate response element binding protein; Rat hepatocyte; Liver type pyruvate kinase; Fatty acid synthase
Funding
- Japan Society for the Promotion of Science
- New Energy and Industrial Technology Development Organization
- Health and Labor Science Research Grant for Research on Human Genome
- Tissue Engineering from the Japanese Ministry of Health, Labor and Welfare
- ONO Medical Research Foundation
- Kao Research Council for the Study of Healthcare Science
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Fibroblast growth factor 21 (FGF21) has beneficial effects of improving the plasma glucose and lipid profiles in diabetic rodents. Here, we investigated carbohydrate response element binding protein (ChREBP) involvement in the regulation of FGF21 mRNA expression in liver. Glucose stimulation and adenoviral overexpression of dominant active ChREBP increased FGF21 mRNA. Consistently, adenoviral expression of dominant negative Mlx inhibited glucose induction of FGF21 mRNA. Furthermore, deletion studies of mouse FGF21 gene promoter (-2000 to +65 bp) revealed a glucose responsive region between -74 and -52 bp. These findings suggest that FGF21 expression is regulated by ChREBP. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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