Journal
FEBS LETTERS
Volume 583, Issue 12, Pages 1976-1980Publisher
WILEY
DOI: 10.1016/j.febslet.2009.05.009
Keywords
Anticoagulant peptide; Factor Xa; Factor XIa; Ancylostoma duodenale
Funding
- Guangdong Natural Science Foundation [04011381]
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A full-length cDNA encoding an anticoagulant peptide, named AduNAP4, was cloned and identified from the human hookworm Ancylostoma duodenale. AduNAP4 has 104 amino acids including a predicted 23-residue signal peptide and shows <= 50% similarity with other known nematode anticoagulant protein/peptide (NAP). AduNAP4 is extremely efficient at prolonging the activated partial thromboplastin time, and is an inhibitor of both fXa (K-i = 7.34 +/- 1.74 nM) and fXIa (Ki = 42.45 +/- 3.25 nM). No fXIa inhibitor has previously been described from other blood-feeding animals. Our results suggest that hookworms have evolved a potent mechanism that interferes with coagulation by inhibition of fXIa to facilitate its blood-feeding lifestyle. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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