Journal
FEBS LETTERS
Volume 583, Issue 12, Pages 2077-2082Publisher
WILEY
DOI: 10.1016/j.febslet.2009.05.035
Keywords
Big brain; Aquaporin-4 (AQP4); Cell adhesion; Drosophila
Funding
- MEXT ( Ministry of Education, Culture, Sports, Science and Technology) of Japan
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The neurogenic gene Drosophila big brain (bib) has a high sequence homology to aquaporin-4. However, its cellular functions in Drosophila neurogenesis have remained elusive. Here we investigated cell adhesion, and the ion and water permeability of Bib. The adhesive function was examined by a cell aggregation assay using L cells. Bib-transfected L cells formed aggregated clusters, while control-L cells remained as a single cell suspension. Ion permeation was not confirmed in L cells stably expressing Bib. When expressed in COS7 cells, Bib exhibited limited water permeability. This newly found cell adhesive function of Bib may be important for Drosophila neurogenesis. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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