Journal
FEBS LETTERS
Volume 584, Issue 3, Pages 583-590Publisher
WILEY
DOI: 10.1016/j.febslet.2009.12.006
Keywords
Anthocyanin; Endothelial cell; Structure-activity relationship; Oxidized low-density lipoprotein; Atherosclerosis; Antiradical activity
Funding
- National Natural Science Foundation of China [30730079]
- National Key Technology RD Program [2008BAI58B06]
- Chongqing Key Laboratory of Nutrition and Food Safety [2006CA1003]
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Anthocyanins may play an important role in atherosclerosis prevention. However, the structure-function relationships are not well understood. The objective of this study was to compare the inhibitory effect of 21 anthocyanins against oxidized low-density lipoprotein-induced endothelial injury to understand the relationship between anthocyanin chemical structure and the endothelial protective properties, measured as cell viability, MDA production and NO release. Additionally, the intracellular anti-radical activity of the selected anthocyanins was investigated to identify the correlation with endothelial protection. Our results provide evidence that the number of -OH in total or in B-ring, 3',4'-ortho-dihydroxyl and 3-hydroxyl are the main structural requirements of anthocyanins in suppressing oxidative stress-induced endothelial injury and such inhibitory effect was significantly correlated with the intracellular radical scavenging activity. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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