Journal
FEBS LETTERS
Volume 584, Issue 4, Pages 719-725Publisher
WILEY
DOI: 10.1016/j.febslet.2009.12.023
Keywords
Zinc; Iron; Hepcidin; MRE-binding transcription factor-1; Metal response element
Funding
- Biotechnological and Biological Sciences Research Council
- Wolfson Trust
- Biotechnology and Biological Sciences Research Council [BB/D521322/1] Funding Source: researchfish
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Hepcidin is a small acute phase peptide that regulates iron absorption. It is induced by inflammation and infection, but is repressed by anaemia and hypoxia. Here we further reveal that hepcidin transcription also involves interactions between functional metal response elements (MREs) in its promoter, and the MRE-binding transcription factor-1. Analysis of hepcidin mRNA and protein levels in hepatoma cells suggests that its expression may be regulated by divalent metal ions, with zinc inducing maximal effects on hepcidin levels. These data suggest that this peptide may be a pleiotropic sensor of divalent metals, some of which are xenobiotic environmental toxins. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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