Journal
FEBS LETTERS
Volume 584, Issue 1, Pages 49-54Publisher
WILEY
DOI: 10.1016/j.febslet.2009.11.059
Keywords
OGT; NCOAT; Hydrogen peroxide; O-GlcNAc; p27Kip1
Funding
- NIH [DK043652]
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The FOXO4 transcription factor plays an important role in cell survival in response to oxidative stress. The regulation of FOXO4 is orchestrated by post-translational modi. cations including phosphorylation, acetylation, and ubiquitination. Here, we demonstrate that O-GlcNAcylation also contributes to the FOXO4-dependent oxidative stress response. We show that hydrogen peroxide treatment of HEK293 cells increases FOXO4 association with OGT, the enzyme that adds O-GlcNAc to proteins, causing FOXO4 O-GlcNAcylation and enhanced transcriptional activity under acute oxidative stress. O-GlcNAcylation is known to be protective for cells under stress conditions, including oxidative stress. Our data provide a mechanism of FOXO4 anti-oxidative protection through O-GlcNAcylation.
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