Journal
FEBS LETTERS
Volume 582, Issue 13, Pages 1783-1787Publisher
WILEY
DOI: 10.1016/j.febslet.2008.04.057
Keywords
serum albumin; antioxidant; oxidative stress; oxidation
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Free radicals are a normal component of cellular oxygen metabolism in mammals. However, free radical-associated damage is an important factor in many pathological processes. Glycation and oxidative damage cause protein modifications, frequently observed in numerous diseases. Albumin represents a very abundant and important circulating antioxidant. This review brings together recent insights on albumin antioxidant properties. First, it focuses on the different activities of albumin concerning protein antioxidation. In particular, we describe the role of albumin in ligand binding and free radical-trapping activities. In addition, physiological and pathological situations that modify the antioxidant properties of albumin are reported. (c) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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